Deputy Ghana Captain Andre Ayew came off the bench to play but could not help his West Ham United side as they were mauled 3-0 by visiting Brighton and Hove Albion.
Brighton took the lead after 10 minutes when the unmarked Glenn Murray headed in Pascal Gross' free-kick.
Moments before the break Jose Izquierdo curled past Joe Hart from distance, despite the England goalkeeper getting a strong hand to the ball.
Murray added his second from the penalty spot in the 75th minute after he was fouled by Pablo Zabaleta.
Although they dominated possession, West Ham had only two shots on target, long-range efforts from Pedro Obiang and Manuel Lanzini.
Ayew was benched for a second game on a row by manager Slaven Bilic but was introduced just before the start of the second half.
The Ghana international however failed to lead his side back into the game as the Seagulls sealed off the victory as a Glenn Murray 75th minute penalty finally undone the under-performing West Ham.