The defending champions take a 2-1 lead to Atteridgeville, on the outskirts of South Africa's capital Pretoria.
"We expect a tough game from SuperSport because they would want to make amends but we are well prepared for anything," said Adjei
Mazembe have been the reference for African club football over the last decade with three Champions League titles, a place in the final of the Club World Cup and success last year in the Confederation Cup.