Arsenal Suffer Huge Injury Blow Ahead of Manchester United Clash With Key Duo Likely to Miss Out

Arsenal are reportedly set to suffer a huge injury blow ahead of their Premier League clash with Manchester United with key duo Alexis Sanchez and Hector Bellerin likely to miss out.

The Gunners head to Old Trafford at the end of the international break to take on Jose Mourinho's United in what is set to be a crucial period in the club's season, but will be without two of their top performers due to injury.

According to theDaily Express, Bellerin picked up a slight ankle knock in his side's 1-1 draw with Tottenham Hotspur in the north London derby during their last domestic encounter, and is said to have exacerbated the problem after training with the U21 Spanish squad earlier this week.

Likely replacements for the young Spaniard at right back will be either Carl Jenkinson, who has just returned from long injury lay-off himself, or Mathieu Debuchy, who has been cast aside in coach Arsene Wenger's squad after failing to secure a position in the starting XI.

Hector Bellerin also already expected to miss Manchester United game with ankle injury that is being assessed. Alexis Sanchez still in Chile

In terms of Sanchez, the Chilean pulled up in training with his country ahead of their clash with Uruguay with a low grade muscle injury to his thigh, and won't be rushed back by Wenger, who has called for the 28-year-old to return to London to recover.

With the in-form Theo Walcott also out injured with a short term issue, it look as though Alex Oxlade-Chamberlain will continue in the side out on the right, with Olivier Giroud leading the attacking line up-front with his first Premier League start of the season.