The Black Stars will hope to begin their quest to make history by becoming the first African country to qualify for for four successive appearances at the FIFA World Cup by beginning their 2018 campaign on a winning note today in Tamale.
Several African powerhouses including Egypt, Nigeria and Cameroun have come close to achieving this feat in the past but have all fallen short at the fourth hurdle.
However, the Stars led by skipper Asamoah Gyan are bent on going one better and have vowed to put the Ugandans to the sword this afternoon in their 2018 FIFA World Cup qualifying opener.
They will however also have to get past two other countries; powerhouse Egypt and minnows Uganda in a round robin in Group E to book their place.
Ghana qualified for her first appearance at the FIFA World Cup in 2006 under Serbian trainer Ratomir Djokovic.
They were led to the 2010 edition by another Serb Milovan Rajevac while coach Kwesi Appiah fronted their disastrous participation in the 2014 World Cup in Brazil.