Asante Kotoko suffered their second consecutive away defeat to ten-man Nkana FC in the CAF Confederation Cup group C match on Sunday in their third Group C match.
The Zambian giants defeated the Porcupine Warriors 3-1 at the Nkana Stadium to go top of the table momentarily.
With the first twenty minutes virtually being a balanced game, the hosts got the advantage to open the scoring in the 21st minute after they were awarded a penalty.
Abdul Ganiu Ismail brought down forward Walter Bwalya inside the box and Freddy Tshimenga stepped up the score.
Burkina Faso import Songné Yacouba drew the Porcupine Warriors level with a blistering free-kick two minutes later.
Ronald "Sate Sate" Kampamba restored the lead for the Likulu side three minutes afterwards after connecting a headed pass from Bwalya.
Kampamba increased the lead for the home side in the 53rd minute after heading home a Gift Zulu cross.
Nkana FC were reduced to ten men after Ghanaian defender Richard Ocran was sent off in the 73rd minute following a second caution.
Nkana will be traveling to Kumasi to face Asante Kotoko in their next fixture next week as they set sights on qualifying from the group stage.