Medeama are aiming to maintain their recent unbeaten streak as they prepare for a clash with Eleven Wonders in Tarkwa.
The Mauve and Yellows only settled for a 0-0 draw with King Faisal but managed a 1-0 victory over Great Olympics in the previous two matchdays.
Samuel Boadu's side are now at the summit of the table with 24 points so far and a victory will help them maintain their grip.
Eleven Wonders are also aiming to maintain their impressive unbeaten run in the league against Medeama. The Sure Wonders have won three of their last five games (W3 D2) including victories over Berekum Chelsea and Great Olympics.
They are now 10th on the league standings with 18 points.
In their previous meeting, Eleven Wonders recorded a 1-0 win on home soil.