Ghanaian duo Mubarak Wakaso and Patrick Twumasi featured in Deportivo Alavés' 2-1 loss to Espanyol in La Liga on Saturday.
Alaves’ Europa League qualification took a dash following the away defeat to Espanyol at the RCDE Stadium.
Adrià Giner Pedrosa broke the deadlock for the hosts in the 19th minute before an unfortunate own goal by Víctor Laguardia at the start of the second half doubled their lead.
Alaves pulled one back in the 56th minute through Jonathan Calleri who pounced on a loose ball inside the penalty area to slot home.
The Ghanaian pair were both brought on in the 79th minute as Alaves went in search of the equalizer to keep their hopes of qualifying for the Uefa Europa League.
However, their best efforts proved futile as a resolute Espanyol defense held on to ensure all three points.