Lyon's captain Memphis Depay is set to miss Euro 2020 after suffering a cruciate knee ligament in Lyon's 1-0 defeat at the weekend.
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The forward has been ruled out for at least six months after being forced off the field in the 45th minute.
Depay, has been integral for the French side this season with nine goals in 12 league appearances.
Lyon sporting director Juninho said: "It's a very bad evening because we lost and because of the lack of quality.
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"The very bad news is also the injury of Memphis, who could be out for a while.
He scored six goals in Euro 2020 qualifying and boss Ronald Koeman already has a shortage of strikers at his disposal.