Raheem Sterling, Fabian Delph and Jordan Henderson have withdrawn from the England squad for the friendlies against Germany and Brazil.
The trio join injured Tottenham pair Harry Kane and Harry Winks in pulling out of Gareth Southgate's squad.
Chelsea defender Gary Cahill has joined up with the national team having been assessed by his club's medical team.
England host Germany at Wembley on Friday and then play Brazil at the same venue on 14 November.
West Brom midfielder Jake Livermore was called up as a replacement following the withdrawal of Kane and Winks.
Striker Kane has a knee injury while midfielder Winks has an ankle problem. The pair had treatment during the 1-0 win over Crystal Palace on Sunday.
Their Spurs team-mate Dele Alli had already withdrawn from the original squad and on Monday England called up Everton defender Michael Keane to replace him.
Tottenham boss Mauricio Pochettino said Winks, who went off at half-time in the Palace match, had twisted his ankle.
Kane received treatment on his knee in the first half and was substituted on 77 minutes for "protection", according to Pochettino.
Source: bbc.com