| Group A | |||
|---|---|---|---|
| 06.03.2021 | 13:00 | Omdurman | El Merriekh (Sudan) – Simba (Tanzania) |
| 06.03.2021 | 19:00 | Cairo | Al Ahly (Egypt) – AS Vita (DR Congo) |
| Group B | |||
|---|---|---|---|
| 05.03.2021 | 19:00 | Algiers | CR Belouizdad (Algeria) – Al Hilal (Sudan) |
| 06.03.2021 | 13:00 | Lubumbashi | TP Mazembe (DR Congo) – Mamelodi Sundowns (South Africa) |
| Group C | |||
|---|---|---|---|
| 06.03.2021 | 16:00 | Johannesburg | Kaizer Chiefs (South Africa) – Petro de Luanda (Angola) |
| 06.03.2021 | 19:00 | Casablanca | Wydad (Morocco) – Horoya (Guinea) |
| Group D | |||
|---|---|---|---|
| 06.03.2021 | 16:00 | Thies | Tuengueth (Senegal) – MC Alger (Algeria) |
| 06.03.2021 | 16:00 | Tunis | Esperance (Tunisia) – Zamalek (Egypt) |
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Source: cafonline.com