Black Stars head coach Otto Addo has admitted his side are under pressure to qualify from Group H after losing 3-2 to Portugal in their 2022 World Cup opener on Thursday.
Black Stars began their campaign on a wrong note, losing narrowly to Fernando Santos' side.
After the goalless first half, Cristiano Ronaldo opened the scoring for Portugal via the penalty spot but Ghana equalised through skipper Andre Ayew from close range.
Portugal responded with two goals in two minutes to seal the points, Joao Felix converting a delightfully clipped finish and substitute Rafael Leao coolly stroking in just seconds after coming on.
Osman Bukari headed in a late consolation for Ghana and there could have been real drama in the ninth minute of stoppage time.
"First of all, surely, we have a chance especially because they played a draw so if we win against South Korea and Portugal win hopefully against Uruguay then we will be second so the chance is still big," coach Addo said after the game.
"And surely it will be very, very tough to beat South Korea because they are good. But now we have to win. We are under pressure but they too."
The defeat means Black Stars are bottom of Group H after Uruguay and South Korea played out a goalless draw earlier on Thursday.
The Black Stars will now switch their attention to their attention to the match against South Korea on Monday before taking on Uruguay on December 2 at the Education City stadium.