In recent years, Ghana has had brothers play against each other at the international level and it is not surprising that, the Williams (Inaki and Nico) will go head to head this time around.
The pair who plies their trade for Athletic Bilbao will not be featuring for the same national team despite being brothers.
While Inaki Williams has decided to play for his native country, his junior brother, Nico Williams has opted to play for Spain.
Both Inaki and Nico Williams are currently at the camp of Ghana and Spain respectively and could make their debut in the September friendlies.
Ghana will play Brazil and Nicaragua on September 23 and 27 in a pre-World Cup friendlies whiles Spain take on Switzerland and Portugal in the UEFA Nations League games on September 24 and 27.
In 2010, Germany-born Ghanaians, Kevin-Prince Boateng and Jerome Boateng decided to go either way at international level.
Prince Boateng, 35, a former Barcelona and AC Milan star opted to play Ghana whiles his younger brother represented Germany.
After making his debut for Ghana in 2010, the enterprising forward who now plies his trade for Hertha Berlin went to make 15 appearances, scoring 2 goals.
He played an instrumental role when the Black Stars reached the quarter-finals of the 2010 FIFA World Cup in South Africa.
Jerome Boateng made his Germany debut in October 2009 and went on to make 76 appearances scoring 1 goal in the process.
He was part of the squad that won the 2014 FIFA World Cup tournament in Brazil.