The Bafana Bafana of South Africa have left Johanessberg for their final Group G game against Black Stars on Sunday.
Hugo Broos' and his charges left their country at 10:00 AM to fly to Accra for the encounter against the four-time Africa champions.
South Africa who sit on top of Group G will be hosted at the Cape Coast Stadium.
Bafana Bafana will be hoping to keep their perfect record in the qualifiers.
The Black Stars meanwhile need a win to ensure they qualify for the Mundial in Qatar next year.
Ghana were held to a 1-1 draw game against Ethiopia at the Orlando Stadium on Thursday.
However, South Africa defeated Zimbabwe by a lone goal to keep their chances alive and need a draw against Ghan to qualify.
After beating Zimbabwe, Hugo Broos' said his side is confident ahead of the game against the Black Stars who need a win to book a place in the playoffs.
"We are in a very good position, we are three points ahead," he said.
“I think Ghana has to score three times to be qualified for the next round.
“So we are happy with it. You know we are three points ahead, but we can lose also," he added.
The game has been scheduled to kick off at 19:00GMT.