Swansea City believe they can expose Manchester United's defensive frailties when the pair face off in the fourth round of the Carabao Cup on Tuesday night.
The Red Devils were surprisingly handed their first loss of the season by Huddersfield Town on Saturday after some poor defending by Victor Lindelof allowed the Terriers to score what was eventually the winning goal.
With Phil Jones and Eric Bailly both unavailable for Tuesday's fixture, Clement is hopeful his side can take advantage of United's instability at the back.
"We've looked at the Huddersfield game and I've spoken about that with the players," said Clement.
"I've told them any team can be vulnerable at any moment, and we've got to make sure we do our bit right.
"They can't make massive changes because they've got injury issues. But we know that whoever they put on the pitch they're going to be good."
Source: tribalfootball.com