Freiburg midfielder Daniel-Kofi Kyereh suffered an injury while on international duty with Ghana.
The 26-year-old was named in Otto Addo-s 29-man squad for friendlies against Brazil and Nicaragua.
Kofi-Kyereh put a splendid performance when Ghana inflicted a 1-0 win over Nicaragua in Lorca, Spain.
The midfielder returned to Freiburg with an injury he sustained during the Nicaragua clash.
"Kofi took a hit," said Freiburg's head coach, in the second international match against Nicaragua.
He could be out of action this weekend for Freiburg due to the latest injury setback
Although Kyereh was not on the training ground on Thursday, but was treated, "but that should normally be good" for the weekend.
Kofi-Kyereh joined Freiburg in the summer transfer window from second-tier side St pauli.