The Ghana FA has declared two national days of prayer and fasting, with Muslims participating on Friday and Christians following suit on Sunday.
It remains to be seen if it will benefit the Black Stars squad, with Ghana entering the finals as the lowest-ranked of the 32 sides, placed 61st in the world.
In Group H, the four-time African champions will meet Portugal and South Korea before facing Uruguay, who knocked Ghana out in the quarter-finals in 2010.
The Black Stars of Ghana played two international friendly games against Brazil and Nicaragua last month. Brazil beat Ghana 3-0 in Le Havre, France and Ghana beat Nicaragua 1-0 in Lorca, Spain.
Ghana will play their last international friendly game against Switzerland on November 17 before heading to the Mundial in Doha, Qatar.
Black Stars fans are currently waiting for the provisional squad for the Mundial.