Hearts of Oak will be without first-choice goalkeeper, Richard Attah and left-back, Raddy Ovouka for their matchday three fixture against Aduana Stars.
The Phobians will host the Dormaa based side at the Accra Sports Stadium on Sunday.
Attah and Ovouka have been invited by their respective country’s for the 2022 Fifa World Cup qualifiers final round of games this week.
Attah was is part of Ghana’s squad set to face Ethiopia and South Africa in the final two games in Group G of the African qualifiers on November 11 and 14 at the Orlando Stadium and Cape Coast Stadium respectively.
Left-back Ovouka was initially snubbed by Congo coach Paul Put but has now earned a late call-up for games against Namibia and Senegal after two players in his position – Bradley Mazikou and Poaty Morgan – pulled out with injuries.
Champions Hearts of Oak have had a difficult start to their title defence so far, drawing their first two games against Legon Cities and WAFA SC.
However, the two players are expected to be available for the Phobians on match-day four when they visit AshantiGold in Obuasi in the matchday four games.