Ghanaian duo, Jordan Ayew and Jeffery Schlupp were in action against Manchester City on Saturday.
Crystal Palace on Saturday hosted the defending champions at Selhurst Park and were hoping to winless run.
The pair started for Palace and put up a good account of themselves.
However, Erling Haaland settled the match from the penalty spot for his 28th goal of the campaign, stroking his 78th-minute spot-kick into the bottom corner after Michael Olise's late challenge on Ilkay Gundogan.
The defeat extends Palace's concerning league winless run to 10 matches - the longest in the division - and leaves Patrick Vieira's side just four points above the relegation places.
Both Jordan and Schlupp were replaced by Eze and Edouard.
Meanwhile, Jordan Ayew has been named in Black Stars squad for the 2023 Africa Cup of Nations [AFCON] qualifiers against Angola later this month.
Ghana will host Angola at the Baba Yara Stadium on March 23 before travelling to Luanda for the return game in four days time.