Senegal forward Sadio Mane will miss the 2022 FIFA World Cup in Qatar because of an injury he sustained in Bayern Munich's 6-1 victory over Werder Bremen in the Bundesliga.
Mane was replaced in the 15th minute by Leroy Sane after going down.
The 30-year-old headed straight down the tunnel for further treatment after being substituted.
He is a key cog of Aliou Cissé's side, who face the Netherlands in their opening Group A game on November 21 before taking on hosts Qatar, then Ecuador at the World Cup.
Mane scored Senegal's winning penalty in the shootout victory over Egypt to clinch their first Africa Cup of Nations title earlier this year.
The former Liverpool player is reported to be suffering from a tendon and is expected to be on the sidelines for several weeks.
Senegal coach Aliou Cissé is due to announce his final squad for the global showpiece which is scheduled for Qatar from November 20 - December 18, 2022.