PSG's Edinson Cavani could be missing as Uruguay and France clash for a World Cup semi-final place on Friday.
The striker has scored three of Uruguay's seven goals at this World Cup, including both in their last-16 win over Portugal, and trained on his own on Thursday in the build-up to the quarter-final.
Manager Oscar Tabarez has led the country since 2006, taking them to fourth place in 2010 and a quarter-final defeat by Brazil four years later, but will be desperate to have Cavani back in his line-up against a France side who finally showed their potency in a 4-3 win over Argentina last time out.
"He's a very important player for us and he was playing very well," Tabarez said.
"As soon as he got injured, he started working hard to recover."
"He is concentrating on his dreams and his hopes, and that's what he's doing right now."
"We issued a press release explaining exactly what kind of exams he had to go through and nobody respected it."
"People started asking other professionals, people who are not here and don't know what is going on."
"I'm not going to say anything else about Cavani because I have already given enough information and I don't want to get into games that are convenient for certain journalists who have a style I don't share."
One player who should be in good condition for the game will be Kylian Mbappe, who scored twice in that last-16 victory for France, with reports since emerging Real Madrid had made a bid for the 19-year-old, which the Spanish club later denied in a statement.
France boss Didier Deschamps said the teenager, only the second in history to score twice a World Cup match, was not letting the attention go to his head.
"What he did against Argentina was very good."
"It put a spotlight on him obviously, and to play like that in such an important match made a name for him," Deschamps said.
"He's had time to digest this and I think he's recovered just like the rest of the team."
"We've all had a few days to recover."
"On Sunday and Monday we savoured the victory, and from Tuesday we started focusing again."
"This is how top-level sport is."
"But we must not now relax and think that everything is easy, that life is beautiful and that less effort is needed."
"But Kylian is smart, he's listening and he knows all that."
Uruguay's style will provide a different test to France than that of Argentina, with their more defensive mindset looking to stifle the kind of free-flowing attacks seen in Saturday's game.
"It's a team with a very different profile to Argentina, extremely well-organised in defence and then very dangerous on the counter-attacks," Deschamps added.
"We'll have to be really patient."
Team News
Cavani's inclusion - or absence - will be the main concern for Uruguay, which will open the door for ex-Middlesbrough man Cristhian Stuani to take his place alongside Luis Suarez.
Blaise Matuidi is suspended for France, meaning there could be a return for Corentin Tolisso, who he replaced following their first match of the tournament, against Australia.
Opta Stats
France have won just one of their eight previous meetings with Uruguay (D4 L3), losing the most recent encounter 0-1 in a friendly in June 2013 (Luis Suarez with the goal).
In World Cup matches, Uruguay are unbeaten against France (W1 D2), beating them 2-1 in 1966 and drawing 0-0 in both 2002 and 2010.
This will be Didier Deschamps' 81st match in charge of France - his first was a 0-0 draw against Uruguay in a friendly in August 2012.
France are unbeaten in their last nine World Cup matches against South American sides (W5 D4), keeping a clean sheet in seven of those games.
Uruguay have won their last four World Cup matches, last winning five in a row between 1950 and 1954.
They've never previously won five in a row in the same World Cup tournament.
This is Uruguay's first appearance in the quarter-final of the World Cup since 2010 when they beat Ghana 4-2 on penalties following a 1-1 draw.
F rance have progressed on four of the last five occasions they've reached the quarter-final stage, with the only exception being a 0-1 defeat against Germany in 2014.
France have won six of their last seven World Cup knockout stage matches (excluding the final), losing the other - with all of these games being settled in 90 minutes.
France's Kylian Mbappe has scored three goals so far this tournament - he's the first teenager to score this many in a World Cup campaign since Pele netted six for Brazil in 1958.
France forward Kylian Mbappe has had five shots at the 2018 World Cup, with all five going on target and three of them ending up as goals.
France forward Antoine Griezmann has scored six goals in his last five appearances in the knockout stages of major tournaments (World Cup and European Championships).
Each of Uruguay's last three goals in the 2018 World Cup have been scored by Edinson Cavani.