Uruguay coach, Diego Alonso says he is looking forward to qualification against Ghana on Friday.
The South Americans will come up against the Black Stars at the Al Janoub Stadium in their final Group H.
The two-time world champions are with just a point after two games. To be able to play in the next round of the tournament, Alonso and his side must beat Ghana.
Kick-off has been scheduled at 15:00GMT.
In South Africa 12 years ago, Uruguay reached the semifinals after ousting Ghana on penalties.
Luis Suarez deliberately handled the ball on the goalline deep into extra time to prevent Dominic Adiyah's goal-bound header, with Asamoah Gyan then missing the subsequent spot-kick.
Despite Suarez's dismissal, Uruguay made the Africans pay in the shootout.
Both sides are bidding to join Portugal in the last 16 from Group H, with South Korea also still in the hunt.
"It's a different story, for both of us," said Alonso following Uruguay's 2-0 defeat to Portugal on Monday.
"We will both go looking for qualifications. Friday will be decisive but it's a very different story to what happened 12 years ago."
Ghana are in pole position to reach the last 16 having beaten South Korea 3-2 earlier on Monday.