Moroccan-born American referee Ismail Elfat has been appointed by FIFA to officiate Ghana's 2022 World Cup opener against Portugal on Thursday.
The game will take place at Stadium 974 (Rass Abou Aboud) at 16:00 GMT.
Elfat, 40, is one of 28 new referees at the global showpiece, which is being held in the Middle East for the first time.
He will be assisted by compatriots Kyle Atkins and Corey Parker, while French official Stephanie Frappart will serve as the fourth official.
Elfath was first a Fourth official in MLS in 2011 and made his MLS refereeing debut in 2012. He became a FIFA listed official in 2016.
Elfath was named the MLS Referee of the Year for the first time in his career on November 18, 2020. He received the honor for a second time two years later on October 14, 2022.
In July 2021, Elfath took charge of three matches at the Tokyo 2020 Olympics, including a quarter -final match between host nation Japan and New Zealand.
Elfath was chosen as one of the two referees from CONCACAF for the 2021 Africa Cup of Nations held in Cameroon from January 9 to February 6, 2022.
Black Stars, who are the lowest-ranked team at the tournament have been drawn in Group H alongside Portugal, South Korea and Uruguay.
After playing Portugal on Thursday, they will take on South Korea and Uruguay on November 28 and December 2 respectively.
The 2022 FIFA World Cup takes place between November 20 and December 18, 2022.
Only three sides from the continent have ever progressed to the quarter-finals; Cameroon in 1990, Senegal in 2002, and Ghana in 2010.
Ghana will be hoping to progress from the group stage at this year's tournament.
Black Stars exited the group stage at the 2014 edition in Brazil after a slow start to the tournament.