Ghana's group opponent Uruguay are holding their breath over Edinson Cavani's fitness after the star remains sidelined having suffered an injury against Barcelona at the end of October.
Cavani will miss Valencia's match against Real Betis on Thursday in La Liga as the Uruguay striker recovers from an ankle injury with few days to the 2022 FIFA World Cup.
The 35-year-old has scored four goals in seven games for Valencia in La Liga this season.
"Edi in the last five or six days has done everything to be able to play but the ankle is very swollen and in pain," Valencia coach Gennaro Gattuso told a news conference on Wednesday.
"He has shown great availability but he can't train."
Uruguay's first game in the World Cup is against South Korea on November 24.
Black Stars have been drawn in Group H alongside Portugal, South Korea and Uruguay.
Ghana will take on Portugal in their first game on November 24 before playing South Korea and Uruguay on November 28 and December 2 respectively.