Moldova-based defender Patrick Kpozo has been handed a call up ahead of the Black Stars 2023 AFCON qualifiers against Angola.
Having being in form, the Sheriff Tiraspol left-back has made the team for the first time under new coach Chris Hughton.
Kpozo was named in the pre-World Cup squad but missed the tournament after the list was pruned to 26 for competition in Qatar.
He will compete with Gideon Mensah for starting role at left-back following the absence of injured Baba Rahman.
Ghana will play host to Angola on March 23 at the Baba Yara Stadium before the reverse fixture in Luanda on March 27.
Ghana lead Group E of the qualifiers with four points, followed by Angola who are also on four points before Central African Republic and Madagascar follow in that order.
Here is the full squad:
Goalkeepers: Lawrence Ati Zigi (FC St. Gallen), Abdul Manaf Nurudeen (Eupen), Joseph Wollacott (Charlton Athletic)
Defenders: Tariq Lamptey (Brighton and Hove Albion), Denis Odoi (Club Brugge), Gideon Mensah (Auxerre), Patrick Kpozo (Sheriff Tiraspol), Daniel Amartey (Leicester City), Joseph Aidoo (Celta Vigo), Mohammed Salisu (Southampton FC), Alexander Djiku (Strasbourg)
Midfielders: Thomas Partey (Arsenal FC), Majeed Ashimeru (RSC Anderlecht), Abdul Salis Samed (Lens), Edmund Addo (Spartak Subotica)
Wingers: Jordan Ayew (Crystal Palace), Osman Bukari (Red Star Belgrade), Joseph Painstil (Genk), Kamal Deen Sulemana (Southampton FC), Ransford Yeboah Königsdörffer (Hamburger SV)
Forwards: Mohammed Kudus (Ajax Amsterdam), Andre Ayew (Nottingham Forest), Kamal Sowah (Club Brugge), Inaki Williams (Athletic Bilbao), Antoine Semenyo (AFC Bournemouth)