Ajax's home Eredivisie match against archrivals Feyenoord was suspended 11 minutes into the second half after disgruntled fans threw flares onto the pitch with the visitors leading 3-0 on Sunday.
When flares were thrown onto the pitch for a second time, with many landing near the goal, the referee stopped the contest and directed the players down the tunnel.
Fans paid no heed as the club displayed the message "Lighting of fireworks is prohibited" on the big screen at the at the Johan Cruyff Arena in Amsterdam.
Ajax were losing 3-0 to rivals Feyenoord before fans threw flares onto the field, leading to the game being abandoned. OLAF KRAAK/ANP/AFP via Getty Images
"De Klassieker has been permanently suspended after repeated fireworks on the field," Eredivisie said in a statement.
"More information on playing out this game will follow later."
Ajax, which have had a poor start to the season with just one win, sit 13th in the 18-team league. They conceded all three goals on Sunday in the first half, leading to discontent from the fans.
The club finished third last season and failed to qualify for the Champions League for the first time in 13 seasons. They had finished champions seven times and runners-up another five over the previous 12 seasons.
Source: espn.co.uk