Roy Hodgson said the Premier League's current directives are taking the joy out of the game for him after 10-man Crystal Palace lost to Liverpool.
Hodgson, 76, expressed his frustration at the interpretation of the handball rule, time-wasting and the decision to allow only one person to stand in the technical area at any one time.
Jordan Ayew was sent off for a second bookable offence with Palace leading 1-0 on Saturday, and Liverpool were able to pull off a late fightback after the forward's 75th-minute dismissal.
There were also two lengthy video assistant referee reviews during the match - one which saw Palace denied a penalty and another which allowed Jean-Philippe Mateta to put the hosts ahead.
"There's a lot more than simple frustration and disappointment, sadness and being gutted about the result," Hodgson told BBC Radio 5 Live.
"It's really a feeling that there are a lot of things going on which are taking the game in the wrong direction at the moment, in my opinion," he added.
"There has always been decisions in matches which affect games irrespective of whether we have one or two referees in the game.
"I would say that the thing that bothers me most is the interpretation of the handball rule, what time-wasting is, the interpretation of the danger of more than one person standing in the technical area to shout advice to the players - that annoys me a damn sight more."
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Palace are winless in five matches and they have managed just one victory in their past nine league games.
That poor run has left them in a precarious position, seven points above the bottom three with a trip to Premier League champions Manchester City next week. Matches against Brighton and Chelsea then follow.
"To say I'm gutted about the way that game went and the result we have had to accept today would be an incredible understatement," Hodgson said.
"I am very disappointed. I think we were very harshly treated. Unfortunately going down to 10 men cost us. I told the referee what I thought at the end of the game. I'm not going to repeat it. He might."
Speaking on BBC's Final Score, former Wales defender Ashley Williams said Palace are too reliant on star players such as injured forward Eberechi Eze.
"Roy Hodgson is frustrated about the refereeing decisions. But 1-0 up against Liverpool at home, they have to win that game," Williams said.
"I can't see where the tide is going to turn. They need Eze back on the pitch but I don't know if they have enough in that squad. Where are they going to get a win?"
Hodgson this week apologised to the Palace fans after saying the boos which greeted the full-time whistle in Wednesday's home defeat by Bournemouth were evidence they had been "spoiled" in recent times.
The former Liverpool and England boss, in his second spell at Selhurst Park after replacing Patrick Vieira in March, said he was "distressed" by his comments.
His side were unable to hold out for an important win in front of their home support after Ayew was booked for time wasting and then for halting a Liverpool counter-attack, adding to the pressure building on Hodgson.
On his side's upcoming run of fixtures, Hodgson said: "They are going to be very difficult games for us to do more than we did today. If we are going to suffer the same sort of fate as we did today with sending offs, injuries, it is going to become even harder."
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Former Liverpool player Stephen Warnock warned Palace, in their 11th consecutive top-flight campaign, against complacency.
"Only a couple of months ago Palace were playing open, expansive football - but in an organised way. It's almost as if they believed in their own hype and games would be comfortable," Warnock said on Final Score.
"They have stopped doing the running. You have got to change that mentality - you can't become complacent. Suddenly the teams in the bottom three are picking up points and you start looking over your shoulders."
Hodgson insisted that his side proved in defeat by Liverpool that they will be safe come the end of the season.
"A Premier League season is 38 games and this group of players will see Crystal Palace through those games and playing in the Premier League next season," Hodgson said.
"If anyone doubts that, I suggest they watch the game today. The bottom line is we did everything to get a result but we haven't got one. We have no more points. I don't have a magic wand, we work very hard."
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Source: bbc.com