Ghanaian duo Abdulai Sabit and Kofi Amankwaa were in action for Getafe in their 5-2 defeat to Barcelona in La Liga on Thursday.
Sabit and Amankwaa climbed off the bench in the second half as their side suffered a humiliating loss.
Messi broke the deadlock before lowly Getafe equalised through Clement Lenglet's own goal.
A mix-up between Sofian Chakla and keeper David Soria restored Barca's lead and Messi made it 3-1.
Enes Unal's penalty gave Getafe hope but goals by Ronald Araujo and Antoine Griezmann sealed the points.
Getafe are 15th on the league table with 31 points after 32 matches played so far.