Ghanaian quartet Jonathan Mensah, Mohammed Abu, Harrison Afful and Lalas Abubakar failed to help their side Columbus Crew progress to the next stage of the MLS Eastern Conference trophy.
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Crew lost 1-0 to Toronto FC in the second leg encounter played on Wednesday.
The Black and Gold conceded on the hour mark with a striker from Jozy Altidore to lose 1-0 on aggregate after a 0-0 first leg.
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Lalas, who played in a left back role, was replaced after 73 minutes and midfielder Abu lasted 83 minutes.
Jonathan Mensah and Harrison Afful played the full throttle of the game.