Medeama coach Samuel Boadu has been forced to make three replacements ahead of their Ghana Premier League clash at the Theatre of Dreams due to an injury to two key players while one has been dropped.
Defenders Ali Ouattara and Philip Osei who have been impressive since the start of the season did not make the trip after sustaining injuries in their 1-0 win over Asante Kotoko on Wednesday.
Midfielder Joseph Cudjoe has been left out and his replacement comes in the form of Jasper Nimo.
Defenders Rashid Alhassan and Fatawu Sulemana could make their Premier League debut after being named in an 18-man squad.
The Mauve and Yellows travel to a familiar territory seeking to maintain their blistering start to the campaign. They have accumulated 10 points and are yet to taste defeat.
They will face their biggest trip of the campaign against a rejuvenated Dreams FC side who have equally been impressive so far.