Premier League champions Ashantigold will host Liberty Professionals at the Len Clay Stadium later tomorrow after managing a 1-1 draw Dreams FC last Sunday.
The Miners have struggled all season to defend their title and are currently placed 10th on the log while struggling Liberty faces uplift when they both lock horns.
In the other matches, Inter Allies will welcome a resurgent Ebusua Dwarfs side to the Tema Sports Stadium while Berekum Chelsea play Sekondi Hasaacas.
Also Techiman City will engage New Edubiase in a fiercely conested fixture.