Medeama will be boosted by the return of Black Stars trio ahead of their trip to Egypt for the CAF Champions League group stage opener against giants, Al Ahly.
The Yellow and Mauves are in Cairo this weekend for a highly competitive clash against the record Champions League holders.
However, Jonathan Sowah, Fatawu Hamidu and Nurudeen Abdulai, who were on national duty are expected to team up with the Yellow and Mauves on Wednesday for their trip to Egypt.
The Black Stars trio arrive in Ghana on Wednesday and will immediately leave for Cairo for the CAF Champions League group opener.
Sowah made his competitive debut for the Black Stars in the World Cup qualifier against Comoros after coming on as a late substitute in the game.
Meanwhile, Hamidu and Abdulai watched from the bench as Ghana succumbed to a 1-0 defeat at the Moroni Stadium.
Twenty-one players and 11 backroom staff will embark on the journey to Egypt as the Ghanaian champions make their first-ever appearance at the group stage of the elite African competition.
Medeama made it to the group stage of the CAF Champions League for the first time in their history after eliminating Remo Stars and Horoya AC of Nigeria and Guinea respectively.
The Mauve and Yellow will also face Young Africans of Tanzania and CD Belouizdad of Algeria in Group D of the competition.