The Black Stars midfielder was a 71st-minute substitute for Davide Biondini as coach Eusebio Di Francesco sought a lifeline with Lazio leading.
The hosts went ahead via Senad Lulic on 50 minutes and doubled their lead five minutes later through Ciro Immobile, but the visitors had a quick response as Gregoire Defrel notched one back just two minutes later to set up a nervy finish.
It was Duncan’s first appearance since returning from an injury which he picked up on September 21 against Chievo. He was unused in matches against Bologna and Roma last week.
The 23-year-old has given Ghana coach Avram Grant a boost ahead of his squad announcement for next month’s 2018 World Cup qualifier against Egypt in Alexandria on November 13.